Inhibitory Effects of Swietenia Mahagoni Seeds Extract on Α-Glucosidase and Α-Amylase

This study analyzed the inhibition activity of swietenia mahagoni seeds extract on α-glucosidase and α-amylase enzymes inhibition assays. swietenia mahagoni seeds were extracted by using supercritical carbon dioxide (sc-co2) extraction at pressures of 20- 30 mpa and temperatures of 40- 60°c. the oil yields obtained were analyzed with α- glucosidase and α- amylase enzymes inhibition assays. all data obtained were expressed as mean ± standard deviation for triplicate experiments. one way analysis was used for statistical significance by using statistica software version 7.0 (startsoft, eua) and ic50 (extract concentration causing 50% enzyme inhibitory) was determined by using graphpad prism 6.0 software. swietenia mahagoni seeds extract have a strong inhibition of α-glucosidase enzyme activity (98.4% ± 0.2) but a moderate inhibition of α- amylase enzyme activity (34.9% ± 1.2). these findings implied that swietenia mahagoni seeds extract could be an effective natural antidiabetic agent.