CRP, AN INFLAMMATORY BIOMARKER IN TYPE 2 DIABETES MELLITUS

Objective: to find out hs-crp levels in type 2 diabetic patients with and without chd and to further evaluate association of hs-crp with glycosylated hemoglobin and lipid profile. methodology: a cross- sectional / analytical study was conducted. group a comprised of 100 type 2 diabetic patients without chd and group b comprised of 100 type 2 diabetic patients with chd. all the patients were randomly selected from khyber teaching hospital (kth) and hyatabad medical complex (hmc). blood glucose, glycosylated hemoglobin, lipid profile and hs-crp levels were assessed. results: the mean hs-crp, fbs and glycosylated hemoglobin values were significantly (p< 0.05) high in type 2 diabetic patients having chd than type 2 diabetic patients without chd. moreover, hs-crp also showed a significant (p< 0.05) positive association with fbs and hbalc and negative association with hdl-c (p< 0.05). conclusion: raised levels of plasma hs-crp in type 2 diabetic patients may contribute to ongoing atherosclerotic processes leading to the development of coronary heart disease in these patients and this can be used as a marker of development of atherosclerosis in patients with diabetes mellitus.