A COMPARATIVE ANALYSIS OF IN-HOSPITAL LEFT VENTRICULAR FUNCTION IN PATIENTS WITH SUCCESSFUL OR UNSUCCESSFUL STREPTOKINASE THROMBOLYSIS FOLLOWING ACUTE MYOCARDIAL INFARCTION

Objective: to compare in-hospital left ventricular function in patients with unsuccessful and successfulthrombolysis presenting with acute myocardial infarction treated with streptokinase.methodology: this comparative study was conducted at department of cardiology, lady reading hospitalpeshawar, from october 2006 to october 2007. two hundred patients with first acute myocardial infarctionwere divided into two groups: group a (successful thrombolysis) and group b (unsuccessful thrombolysis),using ecg criteria. to determine left ventricular function, 2-d echo was used.results: group a included 136 (68%) patients and group b included 64 (32%) patients. impaired leftventricular function was found in 41 (30.1%) patients in group a and 41 (64.1%) patients in group b (p<0.001). left ventricular failure was present in 31 (22.8%) patients of group a and 30 (46.9%) patients ofgroup b (p=0.001). cardiogenic shock was diagnosed in 2 (1.5%) patients in group a and 6 (9.4%)patients in group b (p=0.008).conclusion: presence of lvf is strongly associated with unsuccessful thrombolytic therapy in this groupof patients