Anti-mitochondrial antibody negative primary biliary cirrhosis: A case report

Primary biliary cirrhosis (pbc) is an idiopathic,cholestatic destruction of intra-hepatic microscopic bile ducts. up to 80% of the patients presenting with pbc are females. patients usually present with fatigue,pruritis and jaundice. suspicion of pbc arises when cholestasis and cirrhosis are present in middle-aged women. anti-mitochondrial antibodies (ama) are present in 95% of the patients. ama is considered the serological hallmark of pbc,but may be absent in a proportion of these patients. we hereby present a case of ama-negative pbc. © 2016,postgraduate medical institute. all rights reserved.