Causative factors and clinical outcome in Steven Johnson syndrome and toxic epidermal necrolysis

Objective: to identify the main factors causing steven johnson syndrome (sjs) and toxic epidermal necrolysis (ten) and their clinical outcome in the patients in our local setup. methodology: this case series was conducted at lady reading hospital,peshawar. a total of 54 consecutive patients who presented with steven johnson syndrome and toxic epidermal necrolysis over a two year period (2013-2015) were included in the study. relevant information including bio-data,causative agents,duration of hospital stay and outcome in terms of improvement or mortality was collected. analysis was done using spss version 20. results: the mean age of patients presenting with sjs/ten was 25.9±17.4 years with a minimum age of 1 year and a maximum age of 65 years. majority of patients were between 18-45 years of age. the causes identified for triggering sjs/ten were anticonvulsants (38.9%),followed in equal frequency by antibiotics and nsaids (27.8%) while 5.5% of cases were secondary to herpes virus infection. patients had a variable course with 83.3% of patients improving with no sequel on follow-up and 16.7% succumbing to the disease. conclusion: anticonvulsants,antibiotics and nsaids were the most frequently responsible drugs for development of sjs & ten. the observed mortality rate was 16.7%. © 2017,postgraduate medical institute. all rights reserved.