Effect of smoking on interleukin-6 and correlation between IL-6 and serum amyloid a-low density lipoprotein in smokers

Objective: to investigate the effect of smoking on interleukin-6 and to find the correlation between serum amyloid a-low density lipoprotein (saa-ldl) and il-6 in smokers. methodology: the study was a randomized control trial,carried out in army medical college,rawalpindi,from june 2014 to february 2015. three hundred healthy males participated in the study and were divided into two groups. group-i included non-smokers while group-ii were smokers. levels of saa-ldl and il-6 were determined using elisa kit. data were analyzed using t-test. pearson correlation was used to find correlation between saa-ldl and il-6. results: il-6 levels were high in the smokers than in non-smokers. the mean of il-6 levels of group i and group ii was 40.03 ±8.06 and 50.43 ±19.67 respectively. the difference was statistically significant (p <0.05). moderate positive association was found between saa-ldl and il-6 in smokers (r =0.651,n =150,p <.05). conclusion: positive association was found between smoking and il-6. statistically significant moderate positive association between saa-ldl and il-6 in smokers shows that changes in one are associated with changes in other and vice versa. © 2017,postgraduate medical institute. all rights reserved.