Systematic review and meta-analysis of association of β2-adrenergic receptor gene polymorphisms with nocturnal asthma

Objective: to integrate the quantitatively existing evidences on nocturnal asthma and their association with β2-adrenergic receptor (arg16gly and glu27gln) polymorphism. methodology: the whole procedure for systematic review and meta-analysis was conducted following prisma guidelines. the following databases ovid,pubmed,wiley online library,springer link and the web of knowledge were searched for relevant articles. random effect meta-analysis was conducted. heterogeneity was evaluated by i2 statistic. the funnel plots and the eager tests were used to assess the small study biases and potential publications. results: this systematic review and meta-analysis comprised a total of 9 studies. the brief statement estimates suggested heterozygous arg/gly (or =2.32; 95% ci =1.53-3.54; p value =<0.001),homozygous gly (or =4.78; 95% ci =2.60-8.77,p-value =<0.001) and gly allele (or =1.71,95% ci =1.14-2.56,p-value =0.009) was significantly associated with nocturnal asthma. while glu27gln polymorphism did not showed significant association with nocturnal asthma both in genotype (or =1.28; 95% ci =0.63-2.59; p-value =0.496) and allelic (or =1.65; 95% ci =0.64-4.27; p-value =0.301) analysis. conclusion: heterozygous arg/gly,homozygous gly/gly and gly allele were found to be significantly associated with nocturnal asthma. © 2017,postgraduate medical institute. all rights reserved.