A single dose of propofol can produce excellent sedation and comparable amnesia with midazolam in cystoscopic examination

Background: in this study we compared the sedative and amnesic effects of propofol with midazolam in cystoscopyexamination.methods: this prospective clinical trial was done on 44 adults, with american society of anesthesiology physicalstatus i, ii, iii, who were candidate for cystoscopic examination. patients were recruited according to convenience samplingmethod and randomized into two equal groups. in study group, propofol plus fentanyl and in control group midazolamplus fentanyl were given intravenously. vital signs and sao2, the number of patients movements, presence ofeyelid movements and verbal contact all at the first and 10th minutes after beginning the procedure were recorded. also,frequency distributions of patients recalls, vas (visual analog scale) for pain and vas for satisfaction scores wereevaluated in recovery room.results: frequency distribution of patients movements, frequency distribution of verbal contact and eyelid movementsat the first and 10th minutes were higher in midazolam group (p<0.05). there were a lower vas pain score and highervas satisfaction score in propofol group (p = 0.009 and p = 0.041 respectively).conclusions: propofol was more effective than midazolam in inducing deep sedation and immobility in patients undergoingcystoscopy examination, without interfacing patients with additional danger.