Congenital cardiac malformations in congenital hypothyroid patients in Isfahan

Background: co ngenital hypothyroidism (c h) often seem s to be associated with other congenital abnormalit ies ,mostl y card iac in nature. the aim of thi s study was to determine the pre valence of card iac malformations in pat ientswith ch diagnosed during ch sc reening program in isfahan.methods: in this cross-sec tio nal study, cardiac malformations were determined in ch patients were compared to controlsusing echocardiography. th e association between cardiac malformations and mean t4 and tsh concentrations,etiology of ch according to radiologic findings and permanent and tran sient ch were studied in ch patients.results: overall, 96 and 59 subjects were included in the case and control groups, respectively. cardiac malformationswere present in 30.2% (n = 29) and 15.2% (n = 9) of case and control groups, respectively; i.e. a higher prevalencein ch patients than in controls (p = 0.03). the prevalence of cardiac malformations without patent foramen oval was6.25% (n = 6) in ch pat ients and 1.7% (n = i) in control group (p = 0.1). there was no significant association betweenthe presence of cardiac malformations and the aforementioned variables.conclusions: high prevalence o f cardiac malformations in ch pat ients strongly suggests the potential involvement ofgenetic factors in the pathogenesis of ch. this emphasizes on the necessity of genetic studies involving ch patients.