The effect of Consanguineous Marriages on Congenital Malformation

Consanguinity has been a long-standing social habit among some of iranians . the estimation of consanguinityratios in different parts of iran ranged from 30 to 85%. th is study aimed to delineating the role of consanguinityon cong enital .malformations in khominishahr rural population, isfahan, iran .methods: in a case-control study, 518 malformed population (case group) and 518 normal subjects (control group)were randomly selected from khominishahr rural population, from july to november, 2003 .results: the frequency ofconsanguinity of par ent's was 59.7% in case group and 31.5% in control group . this differentwas statistically significant (p < 0.00 i).conclusion: family history of congenital malformation may play an important role in the high rates of congenitalmalformation.