The preventive Role of Topical Timolol in Treatment of Migraine Headaches

Tbere are many various hypotheses about pathophysiology of migraine beadaches. one of them is autonomicnervous system disturbance, but the exact location of the disturbance is not well known. since most of migraineattacks are accompanied with a retro-orbital pain, we assessed tbe efficacy and safety of topical timolol on blockage of~ adrenergic receptors for preventing migraine headaches.methods: in a clinical trial study, 43 migraine patients (7 male and 36 female ) were studied in two neurology clinics inisfahan. timolol maleate (5% eye drop) prescribed twice a day . the patients visited weekly for the first 4 weeks; then8lh and 12th week after the beginning of treatment, and the duration and frequency of attacks were evaluated. the severityof headache measured subjectively.results: tbe patients were aged 14 to 54 years , with mean age of 34.2 years and mean disease duration of 9.5 yearsbefore the study . they had 13.1 headache days per month. after treatment, the frequency of attacks reached to 3.4 attacksper month. the mean duration of each attack were 16.4 hours before treatment and 2.1 hours after treatment byusing timolol eye drop which were significantly different (p