Is There Any Association Between ERp Gene Polymorphism and Infertility in Iranian Men?

A significant proportion of infertile men with azoospermia and severe oligoazoospermia have a geneticetiology for their reproductive failure. genetic analysis has major effects on finding the eauses of infertility in last decade,but still in some cases , we still do not have clear answer for our patients. during last years it has become evidentthat endogenous estrogens and estrogen receptors (er) play role in the regulation of testicular function. present studywas performed to evaluate the significance of rsal and alui single nucleotide polymorphism in the erfjgene in infertilepatients in comparison with normal fertile male control.methods: from 120 infertile men referred to our center after ruling out all the known causes of the infertility such aschromosomal abnormalities, v-chromosome microdeletion, and other pathologie disorders, 5 rnl peripheral blood wereobtained for dna extraction. pcr amplification of the polymorphic region was carried out and after running the pcrproducts on 1.5% agarose gel, the frequency of the polymorphism were calculated.results: a 3 times higher frequency of the heterozygous rsal:genotype was found in men with low sperm concentrationcompared to control (p=0.003). in contrast, the proportion of homozygous alul genotype was only 113 in severelyoligoazoospermic men in comparison with control (p=0.03) .conclusion: our results could suggest that erfjand rsal and alui single nucleotide polyrnorphisms on this gene areimportant for spermatogenesis in humans, and could play an important role in the spermatogenesis process in males .also it is possible to conclude that different conditions of infertility may not have genetic predisposition in common.