Serum anti-inflammatory cytokines for the evaluation of inflammatory status in endometriosis

Endometriosis is a frequent gynecologic disease with a severe impact on the quality of life in the affected women; its pathogenesis is yet to be fully understood,with an altered immunity as a possible key factor. the present study aimed to investigate the serum anti-inflammatory cytokine profile in the patients with endometriosis compared with the healthy controls. materials and methods: one hundred and sixty women were included,divided into two study groups (group i — endometriosis; group 2 — healthy women). we evaluated the serum levels of interleukin-1 receptor antagonist (il-1ra),il-2,il-2r,il-4,il-10,il-13,and il-15 with the use of human multiplex cytokine panels. statistical analyses (normality distribution analysis,independent t-test,mann–whitney u-test) were performed using ibm spss software (version 22.0) and graphpad prism (version 5.00); receiver operating characteristic curve were used to demonstrate the diagnostic performance of the studied markers. results: the mean serum level of il-1ra,il-4,and il-10 were significantly higher in women with endometriosis compared to women free of disease from the control group (30.155,138.459,and 1.489,respectively,compared to 14.109,84.710,and 0.688,respectively; p < 0.001,p < 0.001,and p = 0.002,respectively.). no significant differences in the mean serum levels of il-2,il-13,and il-15 were observed between the studied groups and il-2r had a very low detection rate. conclusion: endometriosis is associated with elevated levels of anti-inflammatory cytokines,il-1ra,il-4,and il-10,markers that have a potential role as a prognostic factor for endometriosis. © 2015 journal of research in medical sciences.