Serum levels of glucagon-like peptide (GLP)-1 and GLP-2 in patients with Hashimoto’s thyroiditis

Background: the influence of hashimoto’s thyroiditis (ht) with subclinical hypothyroidism or euthyroid status on the alteration of glucagon-like peptide (glp)-1 and glp-2 levels remains uncertain. materials and methods: twenty-four untreated ht patients with subclinical hypothyroidism,24 euthyroid ht patients,and 24 age- and gender-matched controls were enrolled in the study. the levels of glp-1,glp-2,glucose,glycated albumin,insulin,thyroid hormone,and thyroid autoantibodies were measured and evaluated. results: the levels of glp-1,blood glucose,and triglyceride were higher in ht patients with subclinical hypothyroidism than in controls (all p < 0.05,respectively). however,the above variables,including glp-2,were similar in euthyroid patients and controls. neither glp-1 nor glp-2 was correlated with thyroid hormone,thyroid autoantibodies or metabolic parameters. conclusion: the serum levels of glp-1,not glp-2,were increased in patients with subclinical hypothyroidism. our data suggest that subclinical hypothyroidism affects circulating glp-1 levels. © 2015,journal of research in medical sciences. all right reserved.