Aggressive angiomyxoma of the vulva: dramatic response to gonadotropin-releasing hormone agonist therapy

Aggressive angiomyxoma is a rare soft tissue neoplasm that usually arises within the perineum. it often occurs as a vulvarmass and clinically simulates a bartholin's gland cyst. most patient s are in the second or third decade of life, butsome cases have also been reported in children. this is the report of a 21 year old woman with 4.5 x 3 x 1.5 em mass inright labia major. the patient underwent wide local excision surgical treatment. histological examination showed highvascular myxoid tumor containing spindle cells. immunohistochemical study of cells showed positive reaction to estrogenand progesterone and negative reaction to sioo, sma and desmin . treatment with a gonadotropin-releasing hormoneagonist was admini stered to deal with residual tumor and prevent local recurrence for 6 months