Prediction of kidney survival in children with primary focal segmental glomerulosclerosis (a two-center study)

Backgrould: focal segmental glomerulosclerosis (fsgs) is one of the most common glomerulopathies in childrenleading to end stage renal disease (esrd). different values of median renal survival have been reported among differentethnicities and races. many factors are assumed to be responsible for esrd in these patients. in this study, we triedto determine median renal survival (mrs) and also some clinical and histopathological features predisposing fsgspatients to esrd in two referral hospitals in tehran.methods: the study involved 103 fsgs patients (61 males and 42 females) with a mean age of 7.08 ± 0.68 years. thediagnosis was made based on kidney biopsies. all kidney biopsies were studied by light and immunofluorescent microscopes.ocular grids (counting squares) were used as the standard method to calculate the percentage of cortical interstitialfibrosis (cif). the percentage of glomerular sclerosis was presented as renal injury score. glomerular filtration rate(gfr)s50 mllmin was considered as renal death or the end point. patients were followed for i to 15 years, until occurrenceofrenal death.results: the mrs was 9.04 (plus-minus) 1.8 yrs. the renal survival reached 72%,47% and 17% after 5, 10 and 15 years, respectively.univariate analysis showed significant reverse correlation (p(less than)0.05) between renal survival and the followingvariables: hypertension, anemia, gfr at the time of first admission and also renal injury score(greater than)50%, peritubular fibrosis,periglomerular fibrosis, tubular atrophy and cif:20%. however, multivariate analysis revealed only a reverse correlationbetween renal survival with cif?:20% and also hypertension (p