Univariation and multiple linear regression analyses for 23 single nucleotide polymorphisms in 14 chronic glomerular disease’s predisposing genes and systemic lupus erythematosus in Han Chinese

Systemic lupus erythematosus (sle) is a prototypical autoimmune rheumatic disease principally affecting women during childbearing years. it is the most heterogeneous autoimmune disease that affects multiple organs. however, the exact pathogenesis of sle remains uncertain, and might be involving numerous genes which leads to inconsistent findings in genetic studies. one possibility of failure to replicate some single-locus results is that the underlying genetics of sle is based on multiple genes with minor effects.