Cavernous sinus thrombosis syndrome and brainstem involvement in patient with leptospirosis: Two rare complications of leptospirosis

Leptospirosis is a bacterial disease that is caused by pathogenic spirochetes of the genus leptospira. it can affect humans and animals. in humans, it can lead to a wide spectrum of symptoms. it is known as the most common zoonosis in the world. the typical presentation of the disease is an acute biphasic febrile illness with or without jaundice. less common clinical manifestations may result from involvement of different human body systems. in many places, this disease may be under-diagnosed, especially when associated with neurological complications. moreover, without treatment, leptospirosis can lead to organ damages, and even death. neurological complications are uncommon and are reported in a few cases. cavernous sinus thrombosis syndrome and brainstem involvement are rare complications of leptospirosis and are associated with a high mortality risk. to our knowledge, no such cases have been reported in the literature.