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Pharmacokinetic drug‑drug interaction and their implication in clinical management
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نویسنده
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Caterina Palleria ,Antonello Di Paolo ,Chiara Giofrè ,Chiara Caglioti ,Giacomo Leuzzi ,Antonio Siniscalchi ,Giovambattista De Sarro ,Luca Gallelli
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منبع
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journal of research in medical sciences - 2013 - دوره : 18 - شماره : 7 - صفحه:600 -609
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چکیده
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Drug‑drug interactions (ddis) are one of the commonest causes of medication error in developed countries, particularly in the elderly due to poly‑therapy, with a prevalence of 20‑40%. in particular, poly‑therapy increases the complexity of therapeutic management and thereby the risk of clinically important ddis, which can both induce the development of adverse drug reactions or reduce the clinical efficacy. ddis can be classify into two main groups: pharmacokinetic and pharmacodynamic. in this review, using medline, pubmed, embase, cochrane library and reference lists we searched articles published until june 30 2012, and we described the mechanism of pharmacokinetic ddis focusing the interest on their clinical implications.
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کلیدواژه
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Absorption ,adverse drug reaction ,distribution ,drug‑drug interactions ,excretion ,metabolism ,poly‑therapy
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آدرس
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University of Catanzaro, School of Medicine, Department of Health Science, Italy, University of Pisa, Department of Clinical and Experimental Medicine, Division of Pharmacology, Italy, University of Catanzaro, School of Medicine, Department of Health Science, Italy, University of Catanzaro, School of Medicine, Department of Health Science, Italy, Azienda Sanitaria Provinciale Catanzaro, Department of Primary Care, Italy, Cosenza Hospital, Department of Neurology, Italy, University of Catanzaro, School of Medicine, Department of Health Science, Italy, University of Catanzaro, School of Medicine, Department of Health Science, Italy
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Authors
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