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Identification of homogeneously staining regions in leukemia patients
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نویسنده
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Heydarian Moghadam Mohammad ,Movafagh Abolfazl ,Omrani MirDavood ,Ghanati Kiandokht ,Hashemi Mehrdad ,Poursafavi Farhikhteh ,Darvish Hossein ,Zare Abdolahi Davood ,Gholami Milad ,Heidari Rostamy Mohammad Reza ,Safari Shamsi ,HaghNejad Leyla ,Darehgazani Reyhaneh ,Safavi Naeini Niloofar ,Ghandehari Motlagh Mehdi ,Amani Davar
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منبع
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journal of research in medical sciences - 2013 - دوره : 18 - شماره : 4 - صفحه:363 -365
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چکیده
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Homogeneously staining regions (hsr) or double minute chromosomes (dmin) are autonomously replicating extra‑chromosomal elements that are frequently associated with gene amplification in a variety of cancers. the diagnosis of leukemia patients was based on characterization of the leukemic cells obtained from bone marrow cytogenetics. this study report two cases, one with acute myeloblastic leukemia without maturation (aml-m1), aged 23‑year‑old female, and the other with chronic myelogenous leukemia (cml)‑blast crisis, a 28‑year‑old female associated with double minute chromosomes. most cases of acute myeloid leukemia with dmin in the literature (including our cases) have been diagnosed as having acute myeloid leukemia.
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کلیدواژه
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AML ,cancer ,chronic myelogenous leukemia ,homogeneously staining regions dmin ,HSRs ,Iran ,incidence ,leukemia ,new case
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آدرس
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shahid beheshti university of medical sciences, School of Medical Rehabilitation, ایران, shahid beheshti university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, shahid beheshti university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, shahid beheshti university of medical sciences, Research Department, ایران, islamic azad university, Department of Genetics, ایران, shahid beheshti university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, shahid beheshti university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, shahid beheshti university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, shahid beheshti university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, shahid beheshti university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, shahid beheshti university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, shahid beheshti university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, shahid beheshti university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, shahid beheshti university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, tehran university of medical sciences tums, School of Dentistry, Department of Pediatric Dentistry, ایران, shahid beheshti university of medical sciences, School of Medicine, Department of Immunology, ایران
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Authors
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