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New pathogenic variations of mitochondrial DNA in Alzheimer disease!!
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نویسنده
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Sheibani Nia Samira ,Azadfar Parisa ,Akbari Leila ,Assarzadegan Farhad ,Kamalidehghan Behnam ,Maroof Hamid Reza ,Houshmand Massoud
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منبع
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journal of research in medical sciences - 2013 - دوره : 18 - شماره : 3 - صفحه:269 -269
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چکیده
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Alzheimer’s disease (ad) is a neurodegenerative disorder characterized by a gradual loss of episodic memory, in which an interplay between genes and environmental factors are involved. a variety of genetic, medical and environmental factors modulate the ageing‑related processes leading to the devastation of the brain in ad. mutations in mitochondrial dna (mtdna) are suspected to be causally related, since mtdna is maternally inherited in a non‑mendelian way. in this study (research project number #15), the mtdna of 24 ad patients and 100 healthy controls from peripheral blood samples collected from special medical center of tehran, iran during 2010‑2011 were investigated using plymerase chain reaction (pcr) and sequencing methods. the ethical approval and patient informed consent was obtained for the genetic analysis.
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آدرس
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islamic azad university, Department of Biology, ایران, islamic azad university, Department of Biology, ایران, islamic azad university, Department of Biology, ایران, shahid beheshti university of medical sciences, Imam Hossein Hospital, Department of Neurology, ایران, university of malaya, Faculty of Medicine, Department of Pharmacy, Malaysia, National Institute of Genetic Engineering and Biotechnology, Special Medical Center, Department of Medical Genetic, ایران, National Institute of Genetic Engineering and Biotechnology, Special Medical Center, Department of Medical Genetic, ایران
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Authors
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