The effect of salsalate on biochemical factors and endothelial dysfunction of prediabetic patients: A randomized clinical trial

Background: the beneficial effect of using nonacetylated salicylates such as salsalate on decreasing the speed of diabetes progression is a controversial issue. the aim of this study was to evaluate the effect of salsalate on metabolic-syndrome-associated parameters as well as the endothelial function of diabetic and impaired glucose tolerance patients. materials and methods: patients were collected from isfahan endocrinology research center referrals. patients with impaired glucose tolerance diagnosis or newly diagnosed diabetes were enrolled in the study. patients were randomized to receive 1.5 g salsalate (2 × 750 mg) bid or placebo twice a day for 3 months. after the mentioned period, all patients were recalled and complete examination was done; blood samples for biochemistry measurements were drawn (for measuring fbs, post prandial glucose, hba1c, total cholesterol, hdl, tg, ldl) and forearm flow-mediated dilation (fmd) was performed. results: forty patients were enrolled, 32 patients (80%) were female. mean age of patients was 47.15 ± 6.67 years. fbs (fasting blood sugar) was shown to be significantly different between intervention and control subjects before or after treatment. fmd increased significantly in the intervention group (p = 0.004). conclusion: the study showed that salsalate decreased fbs levels of patients. it may also improve endothelial function as fmd increased significantly in the intervention group.