Anti‑inflammatory properties of combined aquatic extract of Ferulago angulata boiss with aerobic exercise on pro‑inflammatory indices in obese males

Background: the application of supplements, herbal extracts, and exercise training for treatment of diseases and reducing chronic inflammation has been increased progressively among people. thus, the aim of this investigation was to study the combined aquatic extract of ferulago angulata boiss with aerobic exercise on pro‑inflammatory indices in obese males. materials and methods: in this semi‑experimental study, forty young obese men (mean and standard deviation of age 34.59 ± 2.24 years, body mass index (bmi) 33.14 ± 2.75 kg/m2) were selected by purposed sampling and were randomly divided into four equal groups (n = 10), training, training‑supplementation, supplementation, and control. participants in the supplementary groups received 50 mg/ml f. angulata extracts daily for 12 weeks. aerobic training program included 12 weeks of training, 3 sessions/week, and each session was 20 min at 60%–%–70% of maximal oxygen consumption. blood samples were taken from the participants 48 h before and after the intervention in fasting state. data were analyzed using dependent t‑test, one‑way analysis of variance, and post hoc tukey test at a significant level of p < 0.05. results: after 12 weeks of exercise and supplementation, levels of interleukin (il)‑6 (p = 0.001), il‑18 (p = 0.03), il‑1 β (p = 0.001), tumor necrosis factor alpha (p = 0.001), weight (p = 0.001), bmi (p = 0.001), body fat percent (p = 0.001), and waist‑hip ratio (p = 0.001) decreased significantly and the mean changes of these indicators in training + supplementation group were significantly augmented as compared to the other three groups. conclusion: it appears that aerobic training plus f. angulata extract consumption have better effect on improvement of serum inflammatory factors in obese young men.