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The association between expression of p53 and aggressiveness of serous adenocarcinoma of the uterine cervix
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نویسنده
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lee sul ,lee hyun joo ,choi kyung un ,kwon byung su ,su dong soo ,jeong dae hoon ,kim geun joo ,lee tae hwa ,roh hyun‑jin ,kim ki hyung
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منبع
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journal of research in medical sciences - 2020 - دوره : 25 - شماره : 5 - صفحه:1 -6
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چکیده
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Background: serous adenocarcinoma of the uterine cervix is an extremely rare variant of cervical adenocarcinoma. this study aimed to evaluate the clinicopathological and molecular features and outcomes of serous adenocarcinoma of the uterine cervix (sacc). materials and methods: this was a retrospective study conducted based on the clinical and pathological data of seven patients diagnosed with sacc after hysterectomy, who were evaluated at the gynecologic oncologic centers between 2010 and 2019. results: five cases were diagnosed at stage ib and two at stage iv. all patients underwent radical hysterectomy with bilateral salpingo‑oophorectomy and subsequently received postoperative radiotherapy or chemotherapy. one patient showed persistent disease, and two patients suffered recurrence. immunohistochemical study showed that three (43%) of the seven patients were positive for p53, and among these three patients, two with diffuse strong p53 expression experienced an aggressive course with recurrences at pelvic lymph nodes, lung, and brain. conclusion: high p53 expression and advanced stage may be associated with poorer clinical outcomes in sacc, which suggest that immunohistochemistry may contribute to the prediction of prognosis.
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کلیدواژه
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Cervix ,clinicopathologic features ,serous adenocarcinoma
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آدرس
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pusan national university, school of medicine, department of obstetrics and gynecology, South Korea. pusan national university hospital, biomedical research institute, south korea, pusan national university, school of medicine, department of obstetrics and gynecology, South Korea. pusan national university hospital, biomedical research institute, south korea, pusan national university hospital, biomedical research institute, South Korea. pusan national university1, school of medicine, department of pathology, South Korea, pusan national university, school of medicine, department of obstetrics and gynecology, South Korea. pusan national university hospital, biomedical research institute, south korea, pusan national university, school of medicine, department of obstetrics and gynecology, South Korea. pusan national university hospital, biomedical research institute, south korea, inje university, college of medicine, busan paik hospital, department of obstetrics and gynecology, South Korea, kosin university, college of medicine, gospel hospital, department of obstetrics and gynecology, South Korea, kosin university, college of medicine, gospel hospital, department of obstetrics and gynecology, South Korea, university of ulsan, college of medicine, ulsan university hospital, department of obstetrics and gynecology, South Korea, pusan national university, school of medicine, department of obstetrics and gynecology, South Korea. pusan national university hospital1, biomedical research institute, South Korea
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Authors
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