|
|
|
|
Metastatic components in colorectal cancer
|
|
|
|
|
|
|
|
نویسنده
|
hajimoradi javarsiani marjan ,haghjooy javanmard shagayegh ,colonna francesca
|
|
منبع
|
journal of research in medical sciences - 2019 - دوره : 24 - شماره : 8 - صفحه:1 -7
|
|
چکیده
|
Recent experiments have shown that cells with different genetic mutations can give rise to cancer transformation, both in vitro and in vivo, supported by the crosstalk between cancer cells and stroma. the stroma and the complex set of involved cells make up the tumor microenvironment that supports the engraftment of metastatic cells. in fact, environmental factors support colorectal cancer arise by formation and maintenance of cancer stem cells (cscs). in this review, we discuss interactions between cscs and their microenvironment that can provide better therapeutic opportunities in the metastatic cancer.
|
|
کلیدواژه
|
Cancer stem cells ,colorectal cancer ,metastasis ,tumor microenvironment
|
|
آدرس
|
shiraz university, school of veterinary medicine, department of basic sciences, Iran, isfahan university of medical sciences, applied physiology research center, cardiovascular research institute, Iran, cattolica delsacro cuore largo francesco university, department of general pathology, Italy
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|