The effects of cranberry juice on serum glucose, apoB, apoA-I, Lp(a), and Paraoxonase-1 activity in type 2 diabetic male patients

Background: type 2 diabetic patients are faced with a higher risk of dyslipidemia and cardiovascular disorders. this study was undertaken to assess the effect of consumption of 1 cup cranberry juice by type 2 diabetic patients on serum paraoxonase-1 (pon-1) activity, apoa-1, apob, glucose, and lp(a). methods: in a double-blind randomized clinical trial, 58 type 2 diabetic male patients were randomly divided to receive 1 cup cranberry juice (cj) or placebo drink daily for 12 weeks. fasting blood were obtained at beginning and at the end of study (12th week). serum glucose and pon-1 activity were measured by enzymatic and colorimetric methods, respectively. apob, apoa-i, and lp(a) were determined immunoturbidimetrically. the data were analyzed by spss version 16. results: there were significant decrease in serum glucose and apob (p>0.05 and p>0.01, respectively) and significant increase in serum apoa-1 and pon-1 activity (p>0.05 and p<0.01, respectively) at the end of study in cj group compared with control group. in cj group at the end of study, there were significant decrease in serum glucose and apob (p<0.01 and p<0.01, respectively) and significant increase in serum apo a-1 and pon-1 activity (p<0.01 and p<0.01, respectively) compared with initial values. in cj group, there was no significant change in lp(a) at the end of study compared with initial values and also compared with control group. conclusion: 1 cup cj for 12 weeks is effective in reducing serum glucose and apob and increasing apoa-1 and pon-1 activity, so may have favorite effects on reducing cvd risk factors in type 2 diabetic male patients.