Does quercetin and vitamin C improve exercise performance, muscle damage, and body composition in male athletes?

Background: quercetin is a bioflavonoid occurs in many food items. some previous studies on quercetin showed the inconsistent results on exercise performance and muscle damage in athletes. the aim of this study was to determine the effects of 8 weeks of quercetin supplementation on exercise performance and muscle damage indices in student athletes. methods: this placebo-controlled, double-blind clinical trial was conducted on 60 male students for 8 weeks. the subjects were randomly assigned to one of the four groups: a) quercetin (500 mg/day quercetin + 200 mg/day placebo), b) quercetin+ vitamin c (500 mg/day quercetin + 200 mg/day vitamin c), vitamin c (500 mg/day placebo + 200 mg/day vitamin c), and placebo (500 mg/day placebo + 200 mg/day placebo). time to exhaustion (tte) for measuring performance, aspartate transaminase (ast), and creatine kinase (ck) for measuring muscle damage and body fat percent (bfp) were measured before and after intervention. results: ck levels reduced in group 1 significantly (p=0.045) and bfp reduced in group 1, 3, and 4, significantly, too (p=0.018, p=0.013, and p=0.043, respectively). whereas statis- tically significant changes between groups were not observed for tte, ast, ck, and bfp after 8 weeks of intervention. conclusions: supplementation with quercetin and vitamin c for 8 weeks did not improve exercise performance but reduced muscle damage and body fat percent in healthy subjects.