Relation of resistin levels with C-reactve protein, homocysteine and uric acid in smokers and non-smokers

Background: the association between c-reactive protein, homocysteine, uric acid levels and cardiovascular risk have been debated for decades. resistin is a newly discovered adipocyte derived cytokine. smoking besides its effect on atherosclerosis, is shown to alter adipocytokine levels. bearing in mind, these complex relationship of resistin with smoking, c-reactive protein, homocysteine and uric acid, we planned to investigate the association of resistin and these cardiovascular risk factors in smoker and non-smoker subjects. methods: we conducted a cross-sectional randomized study including 52 smoking and 33 non-smoking men. after making comparisons of c-reactive protein, homocysteine, uric acid and resistin between the two groups, we classified the subjects according to their insulin resistance and body mass and made again the comparisons.. results: resistin levels were higher in smokers than in non-smokers (p<0.001) and also in insulin resistant than in non-insulin resistant smokers (p<0.05). resistin levels were indifferent in non-smokers as insulin resistance was concerned and in smoker or non-smokers as body mass index was concerned. as all subjects were grouped based on homeostasis model assesment index and body mass index, neither c-reactive protein nor homocysteine and uric acid levels differred. conclusions: we found that smoking may have influence on resistin levels and in smokers, insulin resistance is related to resistin levels, but in smoker and non-smokers body mass may not have any association with resistin. resistin also may not have a role in c-reactive protein, homocysteine and uric acid levels both in smokers and non-smokers.