The effect of omega-3 on the serum visfatin concentration in patients with type II diabetes

Background: visfatin is an adipocytokine which is secreted from adipose tissue and can affect on the diabetes inflammatory reaction and also serum lipids level. on the other hand, omega-3 can also prevent formation of insulin resistance. in the present study, the effect of omega-3 on the serum visfatin concentration was evaluated.methods: 71 women with type ii diabetes were randomly assigned to the group that took omega-3 capsules or control group with placebo capsules. in the first step, study subjects filled a questionnaire collecting their age, height, weight, waist circumference, and hip circumference. also their blood samples were taken for blood tests. in the second step, the intervention was done for 8 weeks and in the third step the aforementioned were collected again. in the blood samples visfatin and lipid profiles (low density lipoprotein [ldl], high density lipoprotein [hdl], triglyceride [tg], and cholesterol), glucose and hba1c were measured. results: there was no significant difference in serum visfatin level between omega-3 and placebo groups before the intervention (p = 0.14), while after the intervention, the mean serum visfatin level in the omega-3 group was significantly higher (p < 0.001). in addition, the mean difference between the serum visfatin level before and after the intervention in both groups was significant (p < 0.001). conclusions: this study showed an increase in visfatin level following consuming omega-3 fats but according to controversial issues on insulin-like function of visfatin, the effects of omega-3 on diabetes should be studied more in further studies.