Association between unfavorable lipid profile and glycemic control in patients with type 2 diabetes mellitus

Background: recent studies hypothesize that dyslipidemia can predict glycated hemoglobin (hba1c) and could be important contributing factor to the pathogenesis of type 2 diabetes mellitus (dm2). therefore,we aimed to evaluate the influence of lipid parameters on long-term glycemic control in dm2. materials and methods: a total of 275 sedentary dm2 (mean [±standard deviation] age 60.6 [±10.0] years) who volunteered to participate in this cross-sectional study were enrolled. anthropometric (body weight,body hight,and waist circumference),biochemical parameters (fasting glucose,hba1c,lipid parameters,creatinine),as well as blood pressure were obtained. results: total cholesterol (odds ratio [or] =1.30,95% confidence interval [ci] [1.02-1.66],p = 0.032),triglycerides (or = 1.34,95% ci (1.07-1.67),p = 0.010),and low density lipoprotein cholesterol (or = 1.42,95% ci [1.10-1.83],p = 0.006) were the independent predictors of higher hba1c,and as they increased by 1 mmol/l each,probabilities of higher hba1c increased by 30%,34%,and 42%,respectively. low level of high-density lipoprotein cholesterol (hdl-c) was found to be the independent predictor of higher hba1c (or = 0.44,95% ci [0.20-0.67],p = 0.039),and increase in hdl-c by 1 mmol/l,reduced the probability of higher hba1c by 56%. conclusion: unfavorable lipid profile can predict hba1c level in dm2 patients. early diagnosis of dyslipidemia,as well as its monitoring and maintaining good lipids control can be used as a preventive measure for optimal long-term glycemic control. © 2017 journal of research in medical sciences.