mupirocin ointment effect on polyposis recurrence after sinus surgery

Introduction: staphylococcus aureus is an identified pathogen involved in the recurrence of symptoms in patients with chronic rhinosinusitis with nasal polyps. we investigated the effectiveness of a topical ointment of mupirocin applied in the nasal vestibule in lessening symptom recurrence and improving the efficiency of functional endoscopic sinus surgery.materials and methods: patients with chronic rhinosinusitis, nasal polyps, and a positive nostril culture for staphylococcus aureus were included in a clinical trial. the right nostril was determined as the intervention group (applying mupirocin ointment) and the left as the control group (applying vitamin a ointment). lund-mackay radiological scores and lund-kennedy endoscopic scores were examined at the time of diagnosis and six months later.results: among 60 patients with chronic rhinosinusitis with nasal polyps, 91.6% were positive for nostril staphylococcus aureus. comparing the average of the diagnostic radiological and endoscopic scores with the follow-up values in both groups indicated a significant improvement after surgery (p-value=0.001, 0.001). however, there was no significant difference in the radiological and endoscopic score improvements between the study and control groups (p-value > 0.56, 0.74).conclusion: nasal mupirocin administration following endoscopic sinus surgery cannot significantly prevent symptom recurrence in chronic rhinosinusitis with nasal polyps.