Assessment of Human Leukocyte Antigen Differences between Smokers with Reinke’s Edema and Those with Laryngeal Cancer

Introduction: the present study aimed to assess human leukocyte antigen (hla) typing differences between smokers with reinke’s edema and those with laryngeal squamous cell carcinoma (scc). materials and methods: the hla class i, ii alleles were examined in 76 unrelated iranian patients using low-resolution polymerase chain reaction with the sequence-specific primer (pcr-ssp) method. results: the frequency of the hla-a*36 allele and hla-b*35 was significantly higher in patients with scc. the frequency of hla-drb1*01 alleles in reinke’s edema was significantly higher, as compared to that in others. in the volunteer group, hla-drb1*13 and hla-drb1*15 were significantly higher. conclusions: as evidenced by the obtained results, hla-a*36 was significantly higher in scc, as compared to that in volunteers and reinke’s edema patients. it can be concluded that being positive for hla-a*36 increases the chance of scc by three times. this result should be further investigated in cohort studies conducted on larger samples. furthermore, hla-a*24 was significantly higher in the volunteer group, as compared to that in other groups. the hladrb1*01 was remarkably higher in reinke’s edema, as compared to that in scc.