Correlation of Serum Vitamin D Levels with Chronic Rhinosinusitis Disease Severity

Introduction: the present study was conducted to investigate the association between the serum vitamin d levels and severity of disease in chronic rhino sinusitis (crs) patients. materials and methods: this prospective cross-sectional study was conducted on a total of 93 patients suffering from chronic rhino sinusitis with nasal polyposis (crs w np). serum level of 25-hydroxyvitamin d was detected using a simple blood test. a22-item questionnaire, namely the sinonasal outcome test-22 (snot-22), was used to assess the subjective disease severity and patients' quality of life. in addition, the radiographic signs of the disease severity were evaluated using the lund-mackay scale (lms). results: the mean age and serum vitamin d level of the patients were measured at 37.7±13.6 years and 24.6±16.9 ng/ml, respectively. moreover, the mean of lms and snot-22 scores were calculated at 14.2±11.2 and 40.8±17.6, respectively. there was a negative correlation between the snot-22 and serum levels of vitamin d (p=0.034). similarly, lms and serum vitamin d levels were correlated negatively (p=0.027). furthermore, the results revealed a direct relationship between lms and snot-22 (p<0.0001). conclusion: according to the obtained results, there was a significant relationship between the serum vitamin d levels and severity of disease in patients with crs w np. therefore, serum vitamin d levels could be added to the routine workup of the patients suffering from crs w np.