The Antiapoptotic Effect of Curcumin in the Fibroblast of the Cochlea in an Ototoxic Rat Model

Introduction: this study aimed to show the potency of curcumin as an antiapoptotic agent that decreases the apoptotic index in the cochlea lateral wall in ototoxic rat models. materials and methods: a total of 24 rattus norvegicus were divided into eight groups: group 1 (control group), group 2 (gentamicin (+)), group 3 (gentamicin + curcumin 20 mg/day), group 4 (gentamicin + curcumin 40 mg/day), group 5 (gentamicin + curcumin 20 mg/day for 7 days), group 6 (gentamicin + curcumin 40 mg/day for 7 days), group 7 (curcumin 20 mg/day for 3 days + gentamicin), and group 8 (curcumin 40 mg/day for 3 days + gentamicin). after the division, the rats were terminated in order to measure the apoptotic index using a terminal deoxynucleotidyl transferase (tdt) dutp nick-end labeling (tunel) assay in the fibroblasts of the cochlea lateral walls. the data were analyzed using analysis of variance (anova), and p<0.05 was used as the cut-off for statistical significance. results: administration of gentamicin showed significant differences (p<0.05) in the apoptotic index. groups undergoing curcumin treatment at a higher dose (200 mg/kg bw) and the prevention groups showed significant differences compared with groups not treated with curcumin conclusion: this study concluded that the apoptotic index can be decreased by curcumin and has a preventive benefit toward ototoxic rat models. the administration of curcumin depended on the dose and duration.