Interleukin-8-251 A/T and CXCR2 +1208 C/T Genes Polymorphisms inChronic Rhinosinusitis

Introduction:il-8 is one of the pro-inflammatory cytokines which can play an essentia i role in the pathogenesis ofchronic rhinosinusitis (crs) as well as nasal polyposis (np). the ability of individuals in producingil-8 is partially determined by il-8-251 arr polymorphism. hence, the aim of the present study wasto investigate the association between il-8-251 aff and cxcr2 +1208cit genes polymorphisms andsusceptibility to crs and np.materials and methods:two hundred and forty fivecrs patients and 204 healthy controls were included in this study. crspatients were categorized by the existence or absence of np. il-8 promoter-251 a/t and cxcr2+1208 crr gene polymorphisms were genotyped via the allele specific pcr (as-pcr) method.results:while no remarkable difference was demonstrated between patients and controls for both cxcr2+1208 crr and il-8 -251 aff polymorphisms, a significant increase in il-8-25 i aa genotype wasdetected in crs patients with np compared to those without it (29.3% and 16.2%, respectively;p=o.03). interestingly, this association got far stronger when only non-asthmatic crs patients weretaken into cons ideration (p=o.oo i).conclusion:the results of the present study indicate that the inheritance of il-8-251 aalle ie is associatedsignificantly with np development in crs patients. therefore, np formation might be a result of theexposure to an intense inflammatory environment, which is more likely in genetically susceptible crspatients.keywords:chronic rhinos inusitis, cxcr2, interleukinl-8, nasal polyposis, polymorphism