توپوگرافی‌های الهام گرفته‌شده از طبیعت در کاربردهای دارویی: مروری بر اثرات توپوگرافی‌های مختلف در انتقال و کارایی دارو

هدف: در تحویل هدفمند دارو، افزایش غلظت دارو در محل مورد نظر و کاهش غلظت آن در محل نامطلوب منجر به بهبود فعالیت دارویی شده و با به حداقل رساندن در معرض قرار گرفتن بافت‌ها و اندام‌های سالم، عوارض جانبی دارو کاهش می‌یابد. از این‌رو، دوز تجویز شده دارو نیز به‌طور معکوس با افزایش فراهمی زیستی و اثربخشی دارو، کاهش می‌یابد که این امر به عبارتی منجر به کاهش هزینه و دفعات تجویز دارو می‌شود. تحویل هدفمند دارو با استفاده از حامل‌ها و مکانیسم‌های مختلف، کنترل بهتری بر سرعت و مدت انتشار دارو دارد. هنگامی‫که نانوتوپوگرافی (ویژگی‌های سطحی در مقیاس نانومتر) الهام گرفته‌شده از پدیده‌های طبیعی در سطوح حاملین دارو شبیه‌سازی می‌شود، به‌عنوان یک محرک فیزیکی منجر به تنظیم برهمکنش بین حامل دارویی و سیستم‌ زیستی هدف می‌شود. هدف از این مقاله، مروری بر اصلاح سطح حامل‌های دارویی و روش‌های ساخت توپوگرافی در مقیاس نانو و نقش رابط‌های زیستی نانوتوپوگرافی در تنظیم عملکرد‌های زیستی از جمله چسبندگی زیستی، بازآرایی سدها، رابط‌های ضد‌ میکروبی و جذب دارو می‌باشد.

nature-inspired topographies for pharmaceutical applications: a review of different topographies effects on drug delivery and efficacy

aim: the field of targeted drug delivery is a rapidly advancing area of pharmaceutical research that focuses on optimizing the efficacy and safety of therapeutic agents. the primary goal is to enhance the concentration of a drug at its desired site of action while minimizing its presence in non-target areas. this selective accumulation not only improves the therapeutic outcomes but also significantly reduces the adverse effects often associated with drug therapies. by employing various carriers and mechanisms, targeted delivery systems can exert precise control over the rate and duration of drug release. this is particularly beneficial in chronic treatments where maintaining therapeutic drug levels is crucial. moreover, the reduction in systemic exposure allows for lower dosages, which inversely correlates with increased bioavailability and drug effectiveness. consequently, this leads to decreased healthcare costs and less frequent dosing schedules, improving patient compliance and quality of life. one innovative approach in this field is the utilization of nanotopography, which involves the replication of natural surface patterns at the nanometer scale onto drug carrier systems. these nature-inspired designs are not merely aesthetic; they play a functional role in modulating the interactions between the drug delivery vehicle and the biological target. for instance, surfaces mimicking the intricate patterns found in natural environments can influence cellular behavior, enhance adhesion, or even provide antimicrobial properties. exploring the nuances of nano-engineered surfaces, this scholarly work reviews how nature-inspired topographies impact drug delivery and efficacy in pharmaceutical applications. it discusses the various methods of fabricating nanoscale topographies and their implications for drug delivery systems. the review highlights how these microscopic landscapes can affect biological functions such as cell adhesion, tissue barrier dynamics, and drug absorption rates. surface modification techniques at the nanoscale are diverse, ranging from simple chemical treatments to sophisticated lithography and microcasting. these methods allow for the creation of specific patterns that can be tailored to enhance the performance of drug carriers. for example, in the context of drug delivery systems, the use of virus-inspired particles has facilitated drug absorption. these bioinspired designs enhance therapeutic outcomes. the role of nanotopography in drug delivery is multifaceted. it can facilitate the formation of bioadhesive interfaces that ensure the drug remains at the site of action for extended periods. this is particularly useful in mucosal drug delivery, where rapid clearance by bodily fluids can be a challenge. additionally, the rearrangement of cellular barriers can be induced by these topographies, allowing for more efficient drug penetration in areas like the blood-brain barrier. antimicrobial interfaces created through nanotopography can prevent the colonization of pathogens on drug delivery devices, reducing the risk of infections. this is especially important in implantable devices where biofilm formation can lead to device failure and serious health complications. in a nutshell, the review article provides a comprehensive overview of how nature-inspired nanotopography can revolutionize the field of drug delivery. by mimicking the wisdom of natural designs, pharmaceutical scientists can develop more effective and safer drug delivery systems that promise to improve therapeutic outcomes and patient care.