Plasma Pharmacokinetics and Muscle Disposition of Marbofloxacin in Chickens

Background: reports on the pharmacokinetics of marbofloxacin in birds are scarce, even when it is a useful tool in poultry production. objectives: determining marbofloxacin kinetic parameters in plasma and muscle arrangement after intravenous and oral administrations and establishing its withdrawal period. methods: clinical healthy chickens (1.08±0.22 kg) were used as experimental subjects, formed in groups of 5. in group a (n= 45) birds received 2 mg/kg of marbofloxacin intravenously while group b (n= 65) was given the same oral dose after fasting for 12 hours. blood samples in the groups and 5 g of muscle were obtained at different times, in a group up to 24 hours and in b group until 120 hours after application. once the samples were obtained and treated, marbofloxacin was quantified by hplc. results: marbofloxacin in fasted chickens is almost completely absorbed (f= 97%), mean residence time is moderate (6.9 hours), with a high volume of distribution. orally, mean residence time is less in plasma (4.9 hours) and the withdrawal time was calculated 2.5 days. conclusions: the kinetic results are consistent with those presented by other fluoroquinolones in poultry and are in line with short production cycles in chickens.