anticancer studies of iraqi-cultivated cydonia oblonga from the family of rosaceae

Background: cydonia oblonga miller is a plant that provides numerous phytochemical benefits that could be used in medicine, such as flavones, flavonols, and their glycosides, in addition to different vitamins and minerals.objectives: this study evaluates the in vitro cytotoxic activity of c. oblonga ethyl acetate of two plant parts (fruit and seeds) against human colon cancer cells (caco-2) using the mtt assay method. methods: in this study, two parts of the c. oblonga plant were used (seeds and fruit) and extracted by using different organic solvents, such as 98% hexane, 80% ethanol, and ethyl acetate. the ethyl acetate extract of both parts was used to evaluate the cytotoxic activity of c. oblonga on human colon cancer cells (caco-2) by using the mtt assay method.results: the ethyl acetate extract of seeds had no considerable cytotoxic effect (p>0.1), while the fruit extract showed a significantly high antiproliferative effect compared to the oxaliplatin anticancer drug (p<0.1).conclusion: the fruit ethyl acetate extract of the quince plant gives significant anticancer activity against colon cancer cells as compared to seed extract which showed no effect.