electrochemical sensor based on crafted thia polymeric crown ether for determination of carbamazepine and ephedrine

Background: direct analysis methods are considered some of the best and easiest tools to quickly determine the amount of active drug in some pharmaceutical preparations. objectives: in this study, an ion electrode is prepared to determine the concentration of a sample of ephedrine (eph) and carbamazepine (cbz) in the medicines produced by some companies directly.methods: cbz and eph drugs ion-selective electrode (ise) based on thia polymeric crown ether (spce-czb and spce-eph) as membrane carrier in polyvinyl chloride (pvc) matrix was successfully fabricated for the determination of cbz and eph drugs.  results: the electrode exhibited a liner nernstian slope response over the range of 1×10^-1 to 1×10^-6 m, and 1×10^-5 to 1×10^-1 with a slope of 28 and 33±2 mv per decade charge, respectively, by using dimethyl phthalate plasticizer and a detection limit of 1×10^-9 m. the response time of the sensor was 10 s. the ise showed a greater preference for cbz and eph over other drugs with good precision.conclusion: the selectivity coefficients of some drugs ranged from 1×10^-5 to 1×10^-1. meanwhile, spce-czb (ise) was successfully used as an indicator electrode for the potentiometric determination of the cbz drug pharmaceutical formulas.