effects of the slow-release curcumin-loaded selenium nanoparticles on experimental peritonitis

Background: new pharmaceutical forms of natural compounds such as curcumin can be an effective intervention to control peritonitis and abdominal adhesion. objectives: this study investigates the effects of slow-release curcumin-loaded selenium nanoparticles (cur@s.n) on some inflammatory biomarkers in experimental peritonitis.methods: after synthesizing selenium nanoparticles (s.n) and (cur@s.n), experimental peritonitis was surgically induced in 80 adult male rats. the control group received no treatment, whereas the other groups received single intraperitoneal doses of 0.25 mg/kg s.n, 50 mg/kg curcumin, and 0.25+50 mg/kg (cur@s.n). blood malondialdehyde (mda), nitric oxide (no), interleukin 6 (il-6), and tumor necrosis factor-alpha (tnfα) were measured on days 3, 7 and 14, and also intra-abdominal adhesion assessment was done.results: on day 3, no levels in all treatment groups significantly decreased (p>0.05), while the lowest level was seen on day 14 in the s.n group (p˂0.05). mda was significantly lower in the s.n and cur@s.n groups than in the control on days 3, 7 and 14 (p˂0.05). tnf-α levels in s.n and cur@s.n groups were significantly lower than in the control group on day 3 (p≤0.05). meanwhile, the s.n group had the lowest level on day 14. il-6 significantly decreased on days 3 and 7 in the cur@s.n and curcumin groups compared to the control group (p˂0.05).conclusion: cur@s.n group possesses significant anti-inflammatory efficacy by reducing mda, no, il-6 and tnf-α, decreasing peritonitis and intra-abdominal adhesion.