Immunohistochemical evaluation of lymphocyte types infiltrate into the canine seminomas

Backgrounds: seminoma is frequently observed in human and canine testes especially in cryptorchids. canine and human seminomas are typically associated with leukocytic infiltration. objectives: we aimed to identify the type of lymphocytes that infiltrate to seminomas. methods: tumor infiltrating lymphocytes were evaluated by immunohistological techniques in 5 dogs with diffuse seminoma. routine pathological examination of these specimens showed diffuse seminoma with tumor infiltrating lymphocytes in all cases. results: lymphocytes in seminomas were predominantly t cytotoxic (cd3+, cd8+) cells. these cells were distributed diffusely, but patchy around the vessels. b-cells were also identified as some rare single cells diffusely scattered in the tumoral parenchyma. conclusions: the results of this study showed that the lymphocyte infiltrating cells are mainly t lymphocytes particularly cd8 cytotoxic type.backgrounds: seminoma is frequently observed in human and canine testes especially in cryptorchids. canine and human seminomas are typically associated with leukocytic infiltration. objectives: we aimed to identify the type of lymphocytes that infiltrate to seminomas. methods: tumor infiltrating lymphocytes were evaluated by immunohistological techniques in 5 dogs with diffuse seminoma. routine pathological examination of these specimens showed diffuse seminoma with tumor infiltrating lymphocytes in all cases. results: lymphocytes in seminomas were predominantly t cytotoxic (cd3+, cd8+) cells. these cells were distributed diffusely, but patchy around the vessels. b-cells were also identified as some rare single cells diffusely scattered in the tumoral parenchyma. conclusions: the results of this study showed that the lymphocyte infiltrating cells are mainly t lymphocytes particularly cd8 cytotoxic type