The Prevalence of Tumor Lysis Syndrome in Children and Adolescents with Cancer in Hamedan Province, Iran

Background: tumor lysis syndrome caused by widespread tumor cell damage may lead to electrolyte imbalances and express as metabolic disturbance causing clinical abnormalities.patients and methods: all patients younger than 16 years with documented malignancy candidate for chemotherapy, in hamedan province of iran were enrolled.results: out of 69 cancer patients the laboratory form of tumor lysis syndrome was detected in 8 patients (11.6%) and its clinical form was observed in 2 patients (2.9%). those two patients with clinical tumor lysis syndrome were treated using hydration, allopurinol, rasburicase and dialysis with good metabolic response.conclusion: although our sample size was limited we found a comparable prevalence of tumor lysis syndrome among our patients in comparison with previous studies. further evaluation of the prevalence of this syndrome among iranian cancer patients is recommended.keywords: tumor lysis syndrome, acute renal failure, oncology, childhood, metabolic, iran.