association between two functional polymorphisms in the mmp-2 promoter and lung cancer incidence in asian population: a meta-analysis study

Background: numerous experiments have been performed to determine the relationship between the matrix metalloproteinase-2 (mmp-2) -1306c/t and -735c/t polymorphisms and the prevalence and progression of lung cancer in diverse populations. however, due to the small sample size and the different results of previous studies, we decided to perform a general meta-analysis on all previous studies about mmp-2 polymorphism and lung cancer in asian population. methods: a complete literature review was conducted within the isi web of knowledge, google scholar, and pubmed databases for studies about mmp-2 polymorphism and lung cancer published from 2002 to 2020. a meta-analysis was conducted, which included more than 2884 cases and 2768 controls. the pooled odds ratio (or) and 95% confidence intervals (ci) were used for dominant, recessive, and co-dominant mmp-9 genotypes to assess the strength of the association. results: a significant correlation was found between the mmp2 c 1306t polymorphism and lung cancer risk (c vs t: or=1.705, p=0.029; cc vs ct+ tt: or=1.16, 95% p=0.000) and for mmp2 c 735t polymorphism (c vs t: or=1.433, p=0.151; cc vs ct+tt: or=1.698, p=0.000). conclusion: the present meta-analysis revealed a significant association between the mmp-2-735c/t and mmp-9-1562 c/t polymorphisms and the risk of lung cancer in asian population.