mir 143 rs353293 g>a polymorphism is not associated with the risk of thyroid cancer in the iranian population: a case-control study

Background: single nucleotide polymorphisms (snps) in the promoter region of mirnas may disturb mirnas processing, alter their expression, and ultimately affect an individual’s susceptibility to cancer. we conducted a case-control study to evaluate the association of rs353293 g>a with the risk of thyroid cancer in the iranian population. methods: 192 patients with thyroid cancer including (papillary, follicular, medullary, and undifferentiated) and 125 healthy subjects were enrolled in this case-control study. rs353293 g>a polymorphism in the promoter region of mir-143/145 were analyzed using polymerase chain reaction–restriction fragment length polymorphism (pcr-rflp) to find the association of this snp with thyroid cancer. logistic regression analyses were conducted to evaluate adjusted odds ratios (ors) for the potential confounding factors (age and sex), and 95% confidence intervals (95% cis) between patients with thyroid cancer and controls. results: we found no association between rs353293 g>a polymorphism and thyroid cancer. conclusion: this study suggests that the functional polymorphism in rs353293 is not associated with development of thyroid cancer. future investigations with larger sample size should be performed to confirm our observations.