Prognostic Impact of Interleukin-10 in Patients with Chronic Lymphocytic Leukemia

Background: several markers are investigated for prognostic purpose in cll patients among which interleukin-10 (il-10) is under more investigation. we aimed to study il-10 level in a group of newly diagnosed patients with cll in a single center in alexandria, egypt. methods: in this study, 80 newly diagnosed patients with cll referring to hematology department of the medical research institute of alexandria university, egypt, and a control group including 40 healthy volunteers were included. zap-70 was determined by flowcytometry and serum il-10 concentration was measured using il-10 sandwich elisa method. results: mean serum il-10 levels were significantly higher among patients with cll. il-10 level was higher in those who were positive for zap-70, binet stage c, rai stage iii-iv and patients with high scores for cll prognostic index (≥8). it showed significant positive correlation with the percentage of zap-70 expression and significant negative correlation to hemoglobin and platelets count. conclusion: serum il-10 in patients with cll at presentation could be used as a prognostic marker for disease progression. measurement of il-10 in low resources areas where flowcytometry is not available could be recommended as a substitute investigation.