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Methylation Status of SMG1 Gene Promoter in Multiple Myeloma
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نویسنده
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gholipour hamid ,abroun saeid ,noruzinia mehrdad ,ghaffari sasan ,maali amirhosein ,azad mehdi
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منبع
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iranian journal of blood and cancer - 2018 - دوره : 10 - شماره : 4 - صفحه:114 -116
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چکیده
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Background: epigenetic modifications, such as methylation can occur in multiple myeloma. smg1is an important gene involved in cell growth which defect in methylation of its promoter leads to reduction of cell apoptosis and uncontrolled proliferation. in this study, we identified the methylation status of the smg1 gene promoter in patients with multiple myeloma. methods: methylation status of smg1 promoter in 9 patients with multiple myeloma and 4 healthy subjects as control was determined by methylationspecific pcr (msp) method. results: smg1 promoter in all myeloma patients was hemi-methylated. meanwhile, in healthy subjects, two cases were hemi-methylated and the other two were normal. conclusion: the results of this study indicated that the prevalence of smg1 promoter methylation in patients with multiple myeloma was higher than general population which could be important in understanding the pathogenesis of the disease.
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کلیدواژه
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Multiple myeloma ,DNA methylation ,SMG1 gene ,Apoptosis ,Promoter gene
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آدرس
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tarbiat modarres university, school of medical sciences, hematology department, Iran, tarbiat modarres university, school of medical sciences, hematology department, Iran, tarbiat modarres university, school of medical sciences, hematology department, Iran, tehran university of medical sciences, student scientific research center, Iran, babol university of medical sciences, faculty of medicine, department of medical biotechnology, Iran, qazvin university of medical sciences, faculty of allied medicine, Iran
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پست الکترونیکی
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haematologicca@gmail.com
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Authors
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