In vitro Evaluation of the antibacterial activity of Platelet-rich Plasma against Selected Oral and Periodontal Pathogens

Background: despite the availability of a wide range of antibiotics, bacterial infections are among important challenges for the healthcare system. therefore, the introduction of new antimicrobial preparations such as platelet-rich plasma (prp) could be suggested theoretically as a preventive measure for bacterial infections. we aimed to evaluate the in vitro antibacterial activity of prp against three common oral bacteria. methods: in vitro antibacterial activity of prp against streptococcus mitis, streptococcus mutans, and neisseria lactamica as three common oral/dental bacteria was determined by disc diffusion method. baseline antibacterial activity was assessed by measuring the diameter zone of inhibition after 24 hours of incubation at 37 °c. results: prp had strong in vitro antibacterial activity against streptococcus mitis, streptococcus mutans and neisseria lactamica with the mean zone of inhibition diameters of 6.73±0.52, 5.8±0.43 and 6.67±0.43 mm, respectively. conclusion: prp is an effective antibacterial agent along with conventional antibiotic treatments against oral and periodontal infections.