Depakine Induced Pseudo-Pelger-Huet Anomaly

Pelger-huët anomaly is a rare benign autosomaldominant anomaly with incidence of about 1 in 6000 persons. pelger-huët cells are morphologically abnormal neutrophils that are either bilobed or completely unsegmented.1,2 it should be differentiated from acquired or pseudo-pelger-huët anomaly (ppha), which has similar morphology and association with different pathological states like myelodysplasia, acute myeloid leukemia (aml), chronic myelogenous leukemia (cml) as well as with certain infections and drugs (valproate and ibuprofen).