Clinicopathological Features of Non-metastatic Triple Negative Breast Cancer

Background: triple negative breast cancer (tnbc) is reported to be associated with a high risk of recurrence, poor overall survival (os), and disease-free survival (dfs) rates. this study evaluated the clincopathological features and survival of non-metastatic tnbc women in the capital of iran compared with other areas of the world. methods: in a retrospective study, 119 women with tnbc based on the criteria were analyzed in this study during 2007-2015. a number of clinicopathological variables, os and dfs were determined in all patients. the mean follow-up was 38 months, which 6 patients lost to follow-up and 16 died of the disease and therefore were censored from the study. results: the mean age at diagnosis was 44.9 years (range: 21-85 years). 31.9% were older than 50 years. the 2- and 5-years os rates were 96% and 88.1%, respectively; whereas, the 2- and 5-years dfs rates were 87% and 74.1%, respectively. right breast tumor and lymph node involvement were more common in patients younger than 50 years, but vascular invasion was more observed in patients aged ≥50 years. there was no significant difference between menopause status, age and ki-67 index for os or dfs. conclusion: the prevalence of tnbc was more common in women younger than 50 years. ki-67 index, menopausal status and age could contribute to prognosis and survival of patients.