Effects of Nano-particles on Histo-pathological changes of the fish

Regarding fast development of the nanotechnology and the probably of it’s side effects on aquatic body organs,this study investigate the effects of nanosilver administration on histology of gill, kidney and biochemicalparameters in common carp. the silver nanoparticles were synthesized in a one-step reduction process in anaqueous solution. 60 o. mykiss were obtained from a local commercial hatchery. fish were divided randomly intofour groups. control group was kept in dechlorinated tap water without any add-on material. experimentalgroups were exposed to concentration of 3, 300 and 1000 mg/l of nanosilver solution for eight weeks,respectively. biochemical analyses of sera, histological alterations of the gill and kidney tissue were done.aneurism in the secondary lamellae and hyperplasia of epithelium in gills, adhesion of the gill lamellae, inducinghyaline cast formation, significant decreasing in the glomerular diameter and formation of intra cytoplasmicvacuoles in the various urinary tubules were seen in experimental groups. the serum levels of total protein wasdecreased significantly (p < 0.05) by increasing nanosilver concentration but alp, ldh, ast and alt increasedsignificantly (p < 0.05). it is concluded that nanosilver induces gill and kidney damages and changes thebiochemical parameters of o. mykiss juveniles in different concentrations.